Audrey was first detected over the southwestern Gulf of Mexico on June 24. It moved slowly northward as it became a tropical storm and a hurricane the next day. A faster northward motion brought the center to the coast near the Texas-Louisiana border on the 27th. Rapid strengthening in the last six hours before landfall meant Audrey made landfall as a Category 4 hurricane. 

The cyclone turned northeastward after landfall, becoming extratropical over northern Mississippi on June 28 and merging with another low over the Great Lakes the next day. The combined system was responsible for strong winds and heavy rains over portions of the eastern United States and Canada.

No reliable wind or pressure measurements are available from Audrey's core at landfall. The main impact was from 8 to 12 ft storm surges that penetrated as far inland as 25 miles over portions of low-lying southwestern Louisiana. These surges were responsible for the vast majority of the 390 deaths from Audrey. Damage in the United States was estimated at $150 million.